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In this study, the influence of amphetamines on GABA (gamma amino butyric acid) was studied in the rat brain (striatum, cortex and hippocampus). According to literature, an increase in GABA is expected after 4 hours, whereas normalization occurs within 24 hours. Rats were therefore injected intraperitoneally with 30mg/kg amphetamine and necropsied after 4 and 24h. Salt solution was injected as a negative control in control animals. Brain samples were derivated by means of OPA/-mercaptoethanol and iodoacetamide, followed by HPLC and electrochemical analysis. First, there was made a linearity curve with the standards of GABA. And when the samples were measured, the concentration can be calculated with the linearity curve. For this results there can be concluded that amphetamines have no effect on GABA concentrations in the different brain levels. But because there were too less samples, the conclusion is not very reliable. Because of the less results, statistical analysis could n

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Schoolbooks - Didactic material

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Schoolbooks - Didactic material